Yes, as long as you have the nether portal chunk loader within spawn chunks commands will work. The only thing that might not work is coordinate based rules since those change in the Nether.
How do you navigate in the Nether?
Bring a stack of gravel and an extra stack of cobble. They are very useful for navigating. Finally torches and food (or at least a bowl. Tons of mushrooms in the nether.)
How do you spawn in different nether?
The only way to get to a different area of the nether, from the overworld, is to pack up your entire overworld operation and move it to a distant location thousands of blocks away.
How many blocks apart are the overworld and Nether portals?
To avoid linking problems, make sure that the Overworld portals are at least 8 blocks apart or the Nether portals 1 block apart, provided that they are linked up correctly.
How to travel far in the overworld using the Nether?
Once you do that you will need to do some math. First find your x and z coords. Then round that to the nearest whole number and divide it by 8. You do this because every 1 block in the nether is 8 blocks in the overworld. WRITE DOWN THE COORDS AFTER YOU HAVE DIVIDED BY 8.
How do you get out of the Nether in Minecraft?
If you set your spawnpoint in the End, you can’t get out because the End Portal to return to the Overworld returns to your spawnpoint, and Nether Portals don’t light in the End. However, you can use setblock to create a portal block which will take you to the Nether and you can return through the Nether Portal to go back to the Overworld.
Where do you find the Nether portal calculator?
When building a portal near the build limit in the Overworld, the portal in the Nether will be near the ceiling. Additionally to the Nether Portal Calculator, there is a 3D distance calculator for getting the precise distance between Nether portals. For more information about Nether Portals, visit the Minecraft Wiki.